Adam10^tm1Zhu
Targeted Allele Detail

Summary

• Symbol: Adam10^tm1Zhu
• Name: a disintegrin and metallopeptidase domain 10; targeted mutation 1, Yuan Zhuang
• MGI ID: MGI:3809598
• Synonyms: Adam10^loxP
• Gene: Adam10 Location: Chr9:70586279-70687511 bp, + strand Genetic Position: Chr9, 39.53 cM
• Alliance: Adam10^tm1Zhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139042
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was surrounded by loxP sites. Germ line, flp mediated recombination was used to remove the neo selection cassette. (J:139042)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam10 Mutation: 38 strains or lines available

References

• Original: J:139042 Tian L, et al., ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol. 2008 Sep;20(9):1181-7
• All: 17 reference(s)