Ccl1^tm1Sman
Targeted Allele Detail

Summary

• Symbol: Ccl1^tm1Sman
• Name: C-C motif chemokine ligand 1; targeted mutation 1, Santos Manes
• MGI ID: MGI:3809665
• Gene: Ccl1 Location: Chr11:82067492-82070638 bp, - strand Genetic Position: Chr11, 49.99 cM
• Alliance: Ccl1^tm1Sman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138942
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 and part of exon 2. Correct targeting was established by Southern blotting. Immunofluorescence staining of inflamed footpads confirmed a lack of gene expression (J:138942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl1 Mutation: 13 strains or lines available

References

• Original: J:138942 Mira E, et al., Statins induce regulatory T cell recruitment via a CCL1 dependent pathway. J Immunol. 2008 Sep 1;181(5):3524-34
• All: 2 reference(s)