Ptpn4^tm1.1Oers
Targeted Allele Detail

Summary

• Symbol: Ptpn4^tm1.1Oers
• Name: protein tyrosine phosphatase, non-receptor type 4; targeted mutation 1.1, Nicolai S C van Oers
• MGI ID: MGI:3809671
• Gene: Ptpn4 Location: Chr1:119580197-119765281 bp, - strand Genetic Position: Chr1, 52.39 cM, cytoband E2
• Alliance: Ptpn4^tm1.1Oers page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138871
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In vivo Cre mediated recombination of Ptpn4^tm1Oers removed exons 21 - 24. RT-PCR confirmed the absence of the full length transcript but detected low levels of a truncated transcript in the thymus, spleen and testes of homozygous mice. (J:138871)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn4 Mutation: 50 strains or lines available

References

• Original: J:138871 Young JA, et al., The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. Mol Immunol. 2008 Aug;45(14):3756-66
• All: 1 reference(s)