Mirc55^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Mirc55^tm1.1Eno
• Name: microRNA cluster 55, including Mir126a through Mir126b; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3809690
• Synonyms: Mir126a^tm1.1Eno
• Gene: Mirc55 Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139708
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence found within the intron of another gene was replaced with an frt- and loxP-flanked neo cassette. The selection cassette was subsequently removed by germ line, cre mediated recombination. Normal expression of the surrounding gene was confirmed by western blot analysis on heart extracts. The absence of the targeted sequence transcript was confirmed by northern blot analysis on lung and heart extracts. (J:139708)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc55 Mutation: 2 strains or lines available

References

• Original: J:139708 Wang S, et al., The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261-71
• All: 11 reference(s)