Tradd^tm1.1Mak
Targeted Allele Detail

Summary

• Symbol: Tradd^tm1.1Mak
• Name: TNFRSF1A-associated via death domain; targeted mutation 1.1, Tak W Mak
• MGI ID: MGI:3809708
• Synonyms: Tradd^KO
• Gene: Tradd Location: Chr8:105985207-105991226 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Tradd^tm1.1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138824
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice containing the Tradd^tm1Mak allele were crossed with Cre-deleter mice to excise exons 3-5 that encode the functional "death domain" of the gene product. Gene inactivation was confirmed by a lack of protein product as determined by western blotting of embryonic fibroblasts from homozygote mice. (J:138824)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tradd Mutation: 18 strains or lines available

References

• Original: J:138824 Chen NJ, et al., Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12429-34
• All: 5 reference(s)