Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Klaus Rajewsky
• MGI ID: MGI:3809723
• Synonyms: R26Stop^FLNikdeltaT3
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139293
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Map3k14 (MGI:1858204)

• Mutation details: The gene lacking the sequence that encodes the TRAF3-binding domain, preceded by a floxed neo STOP cassette and followed by an frt-flanked IRES-EGFP cassette, was knocked into the locus to achieve cre-inducible, ubiquitous expression. Cre mediated removal of the STOP cassette is required for expression. (J:139293, J:157820)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:139293 Sasaki Y, et al., NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10883-8
• All: 11 reference(s)