Apobec3^Rfv3-s
Spontaneous Allele Detail

Summary

• Symbol: Apobec3^Rfv3-s
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; recovery from Friend virus 3, susceptible
• MGI ID: MGI:3809768
• Gene: Apobec3 Location: Chr15:79775860-79800107 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Apobec3^Rfv3-s page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This recessive allele is found in BALB/c, and A.BY strains and is associated with high FV titers after inoculation. This allele produces an alternative mRNA transcript that excludes exon 2 and produces a protein that is 3- to 5- fold less potent in anti-viral activity as the protein encoded by the Apobec3^Rfv3-s allele. (J:138778)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apobec3 Mutation: 127 strains or lines available

References

• Original: J:6147 Doig D, et al., Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production. J Exp Med. 1979 Jul 1;150(1):10-9
• All: 12 reference(s)