Scn8a^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Scn8a^M1Btlr
• Name: sodium channel, voltage-gated, type VIII, alpha; mutation 1, Bruce Beutler
• MGI ID: MGI:3809770
• Synonyms: TremorD
• Gene: Scn8a Location: Chr15:100767739-100943819 bp, + strand Genetic Position: Chr15, 56.39 cM, cytoband F1
• Alliance: Scn8a^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified by its behavioral phenotype among G3 progeny of an ENU mutagenized male mouse. It was mapped to Chr 15 and found to correspond to a G to T transversion at nucleotide position 2919 of the gene (Genbank: NM_001077499). This is predicted to result in replacement of tryptophan by leucine at amino acid position 935 (W935L), which resides in the pore loop between helices S5 and S6 of domain II. (J:139714)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn8a Mutation: 99 strains or lines available

References

• Original: J:139714 Timms H, et al., Record for "TremorD" updated October 7th, 2008. MGI Direct Data Submission. 2008
• All: 1 reference(s)