Xiap^tm1Hs
Targeted Allele Detail

Summary

• Symbol: Xiap^tm1Hs
• Name: X-linked inhibitor of apoptosis; targeted mutation Hermann Steller
• MGI ID: MGI:3809790
• Synonyms: XIAP^deltaRING
• Gene: Xiap Location: ChrX:41148556-41198533 bp, + strand Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
• Alliance: Xiap^tm1Hs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138979
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The first two codons of the RING doman (C449 and K450) were replaced with STOP codons by homologous recombination. This mutation truncates the RING domain and the 13 amino acid sequence between the RING and C terminus. The frt-flanked neo cassette inserted into intron 2 was removed by germ line, flp mediated recombination. (J:138979)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xiap Mutation: 37 strains or lines available

References

• Original: J:138979 Schile AJ, et al., Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev. 2008 Aug 15;22(16):2256-66
• All: 10 reference(s)