Il17rb^tm1Bud
Targeted Allele Detail

Summary

• Symbol: Il17rb^tm1Bud
• Name: interleukin 17 receptor B; targeted mutation 1, Alison L Budelsky
• MGI ID: MGI:3809835
• Synonyms: IL-17RB
• Gene: Il17rb Location: Chr14:29718125-29730853 bp, - strand Genetic Position: Chr14, 18.39 cM
• Alliance: Il17rb^tm1Bud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139080
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was constructed to replace the region of exon 3 that encodes amino acids 38 through 73 with a neomycin selection cassette. Correct targeting was confirmed by Southern blotting. Cultured splenocytes failed to produce IL-5 or IL-13 when incubated with the ligand to the gene product. (J:139080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17rb Mutation: 42 strains or lines available

References

• Original: J:139080 Rickel EA, et al., Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008 Sep 15;181(6):4299-310
• All: 12 reference(s)