Dlx6^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Dlx6^tm1Jlr
• Name: distal-less homeobox 6; targeted mutation 1, John L R Rubenstein
• MGI ID: MGI:3809858
• Synonyms: Dlx6-lacZ
• Gene: Dlx6 Location: Chr6:6863272-6867965 bp, + strand Genetic Position: Chr6, 2.83 cM
• Alliance: Dlx6^tm1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing an IRES sequence, lacZ gene and a neo gene was inserted into the 5' end of exon 3. Trasnlation of one third of the homeodomain and the C-terminus is blocked. (J:139700)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx6 Mutation: 29 strains or lines available

References

• Original: J:139700 Jeong J, et al., Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep;135(17):2905-16
• All: 3 reference(s)