Dnajc24^m1Jkn
Chemically induced Allele Detail

Summary

• Symbol: Dnajc24^m1Jkn
• Name: DnaJ heat shock protein family (Hsp40) member C24; mutation 1, Ian J Jackson
• MGI ID: MGI:3809863
• Synonyms: DPH4 mutant
• Gene: Dnajc24 Location: Chr2:105797054-105833894 bp, - strand Genetic Position: Chr2, 55.46 cM, cytoband E3
• Alliance: Dnajc24^m1Jkn page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis generated a T to A transversion at the splice donor site of intron 4 of the gene locus. This tranversion causes skipping of exon 4 during transcription leading to an in-frame deletion of 23 amino acids. This mRNA transcript is unstable and no protein is produced as determined by immunoblotting on E12.5 homozygote embryos. (J:139665)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnajc24 Mutation: 25 strains or lines available

References

• Original: J:139665 Webb TR, et al., Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. J Cell Sci. 2008 Oct 1;121(Pt 19):3140-5
• All: 1 reference(s)