Stx1a^tm2.1Sud
Targeted Allele Detail

Summary

• Symbol: Stx1a^tm2.1Sud
• Name: syntaxin 1A (brain); targeted mutation 2.1, Thomas C Sudhof
• MGI ID: MGI:3809921
• Synonyms: syntaxin-1A^KO, XRA
• Gene: Stx1a Location: Chr5:135052336-135079954 bp, + strand Genetic Position: Chr5, 74.95 cM
• Alliance: Stx1a^tm2.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138035
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Germ line, cre mediated recombination was used to remove exons 2 and 3. (J:138035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx1a Mutation: 26 strains or lines available

References

• Original: J:138035 Gerber SH, et al., Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion. Science. 2008;321(5895):1507-10
• All: 6 reference(s)