Akap5^tm1Jsco
Targeted Allele Detail

Summary

• Symbol: Akap5^tm1Jsco
• Name: A kinase anchor protein 5; targeted mutation 1, John D Scott
• MGI ID: MGI:3809936
• Synonyms: Akap5^tm1Jscoe
• Gene: Akap5 Location: Chr12:76371665-76380927 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Akap5^tm1Jsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138972
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The loxP sites were introduced into both 5' and 3' of a single coding exon of the gene. A FRT flanked neo cassette was also introduced at down stream of the exon by homologous recombination in ES cells, and after germline transmission, removed by crossing with Flp expressing mice leaving loxP flanked coding exon. (J:138972)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akap5 Mutation: 27 strains or lines available

References

• Original: J:138972 Tunquist BJ, et al., Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62
• All: 8 reference(s)