Akap5^tm1.1Jsco
Targeted Allele Detail

Summary

• Symbol: Akap5^tm1.1Jsco
• Name: A kinase anchor protein 5; targeted mutation 1.1, John D Scott
• MGI ID: MGI:3809938
• Synonyms: AKAP150^-, Akap5^tm1.1Jscoe
• Gene: Akap5 Location: Chr12:76371665-76380927 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Akap5^tm1.1Jsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138972
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked coding exon from Akap5^tm1Jscoe was removed by crossing with Cre deleter mice, Tg(EIIa-cre)C5379Lmgd. FLP mediated recombination removed the FRT-flanked neo cassette. Immunoblots and immunohistochemistry confirmed absence of protein in brain. This is a null allele. (J:138972)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akap5 Mutation: 27 strains or lines available

References

• Original: J:138972 Tunquist BJ, et al., Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62
• All: 9 reference(s)