Kmt5c^tm1Jnw
Targeted Allele Detail

Summary

• Symbol: Kmt5c^tm1Jnw
• Name: lysine methyltransferase 5C; targeted mutation 1, Thomas Jenuwein
• MGI ID: MGI:3810076
• Synonyms: Suv4-20h2^f
• Gene: Kmt5c Location: Chr7:4743114-4750513 bp, + strand Genetic Position: Chr7, 2.74 cM
• Alliance: Kmt5c^tm1Jnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139510
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 1 through 5 floxed. (J:139510)

Generation of the Kmt5c^tm1Jnw and Kmt5c^tm1.1Jnw alleles

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt5c Mutation: 28 strains or lines available

References

• Original: J:139510 Schotta G, et al., A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 2008 Aug 1;22(15):2048-61
• All: 2 reference(s)