Tradd^tm1.1Zgl
Targeted Allele Detail

Summary

• Symbol: Tradd^tm1.1Zgl
• Name: TNFRSF1A-associated via death domain; targeted mutation 1.1, Zhenggang Liu
• MGI ID: MGI:3810080
• Gene: Tradd Location: Chr8:105985207-105991226 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Tradd^tm1.1Zgl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed and FRT flanked neo cassette was inserted in intron 2 and a third loxP site was inserted 3' of exon 5. Mice carring this floxed allele were then crossed to mice carrying Tg(EIIa-cre)C5379Lmgd to excise exons 3-5 which code for amino acid residues 51-310. This results in the deletion of the interactin domains for TRAF2 and RIP (receptor interacting domain). (J:139031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tradd Mutation: 18 strains or lines available

References

• Original: J:139031 Pobezinskaya YL, et al., The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol. 2008 Sep;9(9):1047-54
• All: 4 reference(s)