Trpc3^tm1.1Akon
Targeted Allele Detail

Summary

• Symbol: Trpc3^tm1.1Akon
• Name: transient receptor potential cation channel, subfamily C, member 3; targeted mutation 1.1, Arthur Konnerth
• MGI ID: MGI:3810122
• Synonyms: Trpc3^-
• Gene: Trpc3 Location: Chr3:36674626-36744276 bp, - strand Genetic Position: Chr3, 17.93 cM, cytoband B
• Alliance: Trpc3^tm1.1Akon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was introduced into intron 6 and a floxed PGK-neo cassette was inserted into intron 7. The selection cassette was removed from properly targeted ES cells leaving exon 7 floxed. Mice with the floxed exon 7 were crossed to cre expressing mice to create the knockout allele. (J:139695)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpc3 Mutation: 58 strains or lines available

References

• Original: J:139695 Hartmann J, et al., TRPC3 channels are required for synaptic transmission and motor coordination. Neuron. 2008 Aug 14;59(3):392-8
• All: 58 reference(s)