Dact2^tm1.1Xya
Targeted Allele Detail

Summary

• Symbol: Dact2^tm1.1Xya
• Name: dishevelled-binding antagonist of beta-catenin 2; targeted mutation 1.1, Xiao Yang
• MGI ID: MGI:3810282
• Synonyms: Dpr2^-
• Gene: Dact2 Location: Chr17:14415492-14424595 bp, - strand Genetic Position: Chr17, 8.95 cM, cytoband A2
• Alliance: Dact2^tm1.1Xya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139684
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.7 Kb region containing the first exon (including the translation start codon) and the 5' end of intron 1 was replaced with a floxed neomycin selection cassette. Mice derived from correctly targeted ES cells were crossed to Tg(ELLa-cre)C5379Lmgd mice to delete the selection cassette. No mRNA could be detected in these mice by either RT-PCR or by Northern blot analysis. (J:139684)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dact2 Mutation: 33 strains or lines available

References

• Original: J:139684 Meng F, et al., Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF{beta} signaling. J Cell Sci. 2008 Sep 1;121(Pt 17):2904-12
• All: 1 reference(s)