Olig2^{tm2(TVA,cre)Rth}
Targeted Allele Detail

Summary

• Symbol: Olig2^{tm2(TVA,cre)Rth}
• Name: oligodendrocyte transcription factor 2; targeted mutation 2, David H Rowitch
• MGI ID: MGI:3810299
• Synonyms: Olig2-tva-cre
• Gene: Olig2 Location: Chr16:91022345-91025565 bp, + strand Genetic Position: Chr16, 52.6 cM
• Alliance: Olig2^{tm2(TVA,cre)Rth} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139574
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Olig2^{tm2(TVA,cre)Rth} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Olig2 (MGI:1355331)

• Mutation details: A cDNA encoding the avian specific retroviral receptor (TVA) followed by an IRES-cre and neo cassette was inserted immediately downstream of the translation initiation site. (J:139574)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Olig2 (mouse) Summary of all recombinase alleles driven by Olig2. Alliance mouse Olig2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Olig2^{tm2(TVA,cre)Rth}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Olig2 Mutation: 46 strains or lines available

References

• Original: J:139574 Schuller U, et al., Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12;14(2):123-34
• All: 54 reference(s)