Tg(THY1-SNCA*A30P)M30Sud
Transgene Detail

Summary

• Symbol: Tg(THY1-SNCA*A30P)M30Sud
• Name: transgene insertion M30, Thomas C Sudhof
• MGI ID: MGI:3810438
• Synonyms: M30
• Transgene: Tg(THY1-SNCA*A30P)M30Sud Location: unknown
• Alliance: Tg(THY1-SNCA*A30P)M30Sud page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(THY1-SNCA*A30P)M30Sud expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene construct contains the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. Expression of the transgene is 5-fold higher in the brain and 10-fold higher in the spinal cord. (J:115193)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:115193 Chandra S, et al., Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell. 2005 Nov 4;123(3):383-96
• All: 4 reference(s)