Tnfaip8l2^tm1Yhcn
Targeted Allele Detail

Summary

• Symbol: Tnfaip8l2^tm1Yhcn
• Name: tumor necrosis factor, alpha-induced protein 8-like 2; targeted mutation 1, Youhai H Chen
• MGI ID: MGI:3810526
• Synonyms: TIPE2^-
• Gene: Tnfaip8l2 Location: Chr3:95046832-95049671 bp, - strand Genetic Position: Chr3, 40.74 cM
• Alliance: Tnfaip8l2^tm1Yhcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139785
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Both exons of this gene locus were replaced by a neomycin resistance cassette. RT-PCR on bone marrow confirmed gene inactivation. (J:139785)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfaip8l2 Mutation: 17 strains or lines available

References

• Original: J:139785 Sun H, et al., TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell. 2008 May 2;133(3):415-26
• All: 19 reference(s)