Tshz3^tm1Lafa
Targeted Allele Detail

Summary

• Symbol: Tshz3^tm1Lafa
• Name: teashirt zinc finger family member 3; targeted mutation 1, Laurent Fasano
• MGI ID: MGI:3810527
• Synonyms: Tshz3^lacZ
• Gene: Tshz3 Location: Chr7:36397543-36472978 bp, + strand Genetic Position: Chr7, 22.79 cM
• Alliance: Tshz3^tm1Lafa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138769
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by immunohistochemistry on E15.5 ureters. (J:138769)

Expression

In Mice Carrying this Mutation:	8 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshz3 Mutation: 39 strains or lines available

References

• Original: J:138769 Caubit X, et al., Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008 Oct;135(19):3301-10
• All: 7 reference(s)