Tg(Tek-cre)2352Rwng
Transgene Detail

Summary

• Symbol: Tg(Tek-cre)2352Rwng
• Name: transgene insertion 2352, Rong Wang
• MGI ID: MGI:3810530
• Synonyms: Tg(Tek-cre)1Lfr, Tg(Tie2-Cre)2352, tie2-cre, Tie2Cre
• Transgene: Tg(Tek-cre)2352Rwng Location: unknown
• Alliance: Tg(Tek-cre)2352Rwng page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tek-cre)2352Rwng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tek (MGI:98664)

• Mutation details: A transgenic construct containing sequence encoding cre under the control of of the mouse Tek, endothelial-specific receptor tyrosine kinase (also known as Tie2), promoter was introduced into FVB/N donor eggs. Founder line 2352 was subsequently established. Cre recombinase expression is detected in most endothelial cells and blood islands of the extraembryonic mesoderm by embryonic day (E)7.5, in the dorsal aorta by E8.5 and is very strong in head vasculature by E9. (J:104401)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:104401 Braren R, et al., Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 2006 Jan 2;172(1):151-62
• All: 14 reference(s)