Men1^tm2.1Gfk
Targeted Allele Detail

Summary

• Symbol: Men1^tm2.1Gfk
• Name: multiple endocrine neoplasia 1; targeted mutation 2.1, Graham F Kay
• MGI ID: MGI:3810641
• Synonyms: second line
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm2.1Gfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116086
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Floxed sequence including exon 2 and a neomycin cassette was excised from the gene by the expression of cre recombinase. Exon 2 contained the initiator methionine and 400 bp of coding sequence. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. (J:75116)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm2.1Gfk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:116086 Loffler KA, et al., Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int J Cancer. 2007 Jan 15;120(2):259-67
• All: 3 reference(s)