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Tg(Fabp7-cre,-lacZ)3Gtm
Transgene Detail
Summary
Symbol: Tg(Fabp7-cre,-lacZ)3Gtm
Name: transgene insertion 3, David H Gutmann
MGI ID: MGI:3810647
Synonyms: BLBP-cre, BLBP-cre-lacZ
Transgene: Tg(Fabp7-cre,-lacZ)3Gtm  Location: unknown  
Alliance: Tg(Fabp7-cre,-lacZ)3Gtm page
Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Fabp7-cre,-lacZ)3Gtm expression driven by 1 gene
 
Mutation detailsA 1.6 kb fragment of murine Fabp7 drives expression of a nuclear targeted cre. The transgene also contains and IRES-lacZ sequence. LacZ expression is seen in the ventricular region of the spinal cord and in the hindbrain at E9.5, in thedorsal portion of the rostral neuroepithelium and in the midbrain at E10.5, extending into the ventricular/subventricular regions of the brain by E12.5, and in the ependymal cell layer of the ventricle with distinct labeling in the subventricular zone in young adults. No expression is detected in other organ systems. Three lines were generated with lines 2 and 3 having identical expression patterns. (J:139866)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fabp7 (mouse)
Summary of all recombinase alleles driven by Fabp7.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
involves: 129 * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
 
cn4  Disease Model
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
 
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
 
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
 
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
 
involves: 129S4/SvJae * C57BL/6 * CBA
 
involves: 129S6/SvEvTac * C57BL/6 * CBA
 
Phenotypes:
Affected Systems
show or hide all annotated terms
                 
behavior/neurological
abnormal behavior
abnormal suckling behavior
abnormal voluntary movement
cellular
abnormal neuronal precursor proliferation
digestive/alimentary system
abnormal digestive system morphology
abnormal hindgut morphology
enlarged stomach
abnormal digestive system physiology
endocrine/exocrine glands
N N
endocrine/exocrine gland phenotype
N N
abnormal pituitary gland morphology
small adenohypophysis
abnormal pituitary gland development
small pituitary gland
abnormal pituitary gland physiology
growth/size/body
N N
growth/size/body region phenotype
N N
decreased body weight
postnatal growth retardation
homeostasis/metabolism
abnormal hormone level
decreased circulating growth hormone level
mortality/aging
N N
mortality/aging
N N
premature death
postnatal lethality, incomplete penetrance
neoplasm
increased medulloblastoma incidence
nervous system
nervous system phenotype
N N N N N
abnormal pituitary gland morphology
small adenohypophysis
abnormal pituitary gland development
small pituitary gland
increased medulloblastoma incidence
abnormal brain development
abnormal retrotrapezoid nucleus morphology
abnormal hippocampus morphology
abnormal secondary somatosensory cortex morphology
abnormal CNS glial cell morphology
abnormal astrocyte morphology
increased astrocyte number
increased oligodendrocyte number
abnormal dendrite morphology
abnormal facial nerve morphology
abnormal nervous system physiology
abnormal neuronal precursor proliferation
abnormal pituitary gland physiology
abnormal hypothalamus physiology
respiratory system
decreased pulmonary respiratory rate
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
cn4
IDs
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:139866 Hegedus B, et al., Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007 Oct 11;1(4):443-57
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory