Affected Systems |
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behavior/neurological
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√
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√
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abnormal behavior
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√
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abnormal suckling behavior
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√
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abnormal voluntary movement
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√
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cellular
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√
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abnormal neuronal precursor proliferation
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√
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digestive/alimentary system
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√
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abnormal digestive system morphology
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√
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abnormal hindgut morphology
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√
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enlarged stomach
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√
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abnormal digestive system physiology
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√
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endocrine/exocrine glands
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√
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√
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N
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N
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endocrine/exocrine gland phenotype
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N
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N
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abnormal pituitary gland morphology
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√
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small adenohypophysis
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√
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√
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abnormal pituitary gland development
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√
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small pituitary gland
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√
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abnormal pituitary gland physiology
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√
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growth/size/body
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√
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√
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N
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N
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growth/size/body region phenotype
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N
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N
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decreased body weight
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√
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√
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postnatal growth retardation
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√
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homeostasis/metabolism
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√
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√
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abnormal hormone level
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√
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decreased circulating growth hormone level
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√
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√
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mortality/aging
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√
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N
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N
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√
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mortality/aging
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N
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N
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premature death
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√
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√
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postnatal lethality, incomplete penetrance
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√
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neoplasm
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√
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√
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increased medulloblastoma incidence
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√
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√
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nervous system
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√
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√
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√
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√
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√
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√
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√
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√
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√
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nervous system phenotype
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N
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N
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N
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N
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N
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abnormal pituitary gland morphology
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√
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small adenohypophysis
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√
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√
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abnormal pituitary gland development
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√
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small pituitary gland
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√
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increased medulloblastoma incidence
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√
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√
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abnormal brain development
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√
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√
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√
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abnormal retrotrapezoid nucleus morphology
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√
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abnormal hippocampus morphology
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√
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√
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√
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abnormal secondary somatosensory cortex morphology
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√
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abnormal CNS glial cell morphology
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√
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√
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√
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abnormal astrocyte morphology
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√
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√
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√
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√
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increased astrocyte number
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√
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increased oligodendrocyte number
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√
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abnormal dendrite morphology
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√
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abnormal facial nerve morphology
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√
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abnormal nervous system physiology
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√
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abnormal neuronal precursor proliferation
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√
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abnormal pituitary gland physiology
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√
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abnormal hypothalamus physiology
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√
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respiratory system
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√
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decreased pulmonary respiratory rate
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√
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