Tg(Fabp7-cre,-lacZ)3Gtm
Transgene Detail

Summary

• Symbol: Tg(Fabp7-cre,-lacZ)3Gtm
• Name: transgene insertion 3, David H Gutmann
• MGI ID: MGI:3810647
• Synonyms: BLBP-cre, BLBP-cre-lacZ
• Transgene: Tg(Fabp7-cre,-lacZ)3Gtm Location: unknown
• Alliance: Tg(Fabp7-cre,-lacZ)3Gtm page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Fabp7-cre,-lacZ)3Gtm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fabp7 (MGI:101916)

• Mutation details: A 1.6 kb fragment of murine Fabp7 drives expression of a nuclear targeted cre. The transgene also contains and IRES-lacZ sequence. LacZ expression is seen in the ventricular region of the spinal cord and in the hindbrain at E9.5, in thedorsal portion of the rostral neuroepithelium and in the midbrain at E10.5, extending into the ventricular/subventricular regions of the brain by E12.5, and in the ependymal cell layer of the ventricle with distinct labeling in the subventricular zone in young adults. No expression is detected in other organ systems. Three lines were generated with lines 2 and 3 having identical expression patterns. (J:139866)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fabp7 (mouse) Summary of all recombinase alleles driven by Fabp7. Comparative matrix view of recombinase activities Alliance mouse Fabp7 gene page

Disease models

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:139866 Hegedus B, et al., Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007 Oct 11;1(4):443-57
• All: 22 reference(s)