Kat8^tm1.1Avo
Targeted Allele Detail

Summary

• Symbol: Kat8^tm1.1Avo
• Name: K(lysine) acetyltransferase 8; targeted mutation 1.1, Anne K Voss
• MGI ID: MGI:3810976
• Synonyms: Mof^-
• Gene: Kat8 Location: Chr7:127511689-127525010 bp, + strand Genetic Position: Chr7, 69.83 cM
• Alliance: Kat8^tm1.1Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139761
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette and exons 2 through 5. Reduction in transcript expression was confirmed by northern blot analysis on heterozygous brain, kidney, liver, spleen and testes extracts. (J:139761)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat8 Mutation: 38 strains or lines available

References

• Original: J:139761 Thomas T, et al., Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture. Mol Cell Biol. 2008 Aug;28(16):5093-105
• All: 1 reference(s)