Itm2b^tm1.1Ldad
Targeted Allele Detail

Summary

• Symbol: Itm2b^tm1.1Ldad
• Name: integral membrane protein 2B; targeted mutation 1.1, Luciano D'Adamio
• MGI ID: MGI:3810987
• Synonyms: Bri2^-
• Gene: Itm2b Location: Chr14:73599666-73622729 bp, - strand Genetic Position: Chr14, 38.88 cM
• Alliance: Itm2b^tm1.1Ldad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138796
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted 200 bp 5' of exon 2 and a floxed PGK-neo cassette was inserted in intron 2 via homologous recombination. The floxed PGK-neo cassette and exon 2 were deleted via in vivo Cre-mediated recombination. Western blot analysis of brain membranes from homozygous mice confirmed the absence of protein expression. (J:138796)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itm2b Mutation: 18 strains or lines available

References

• Original: J:138796 Matsuda S, et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008 Aug 27;28(35):8668-76
• All: 5 reference(s)