Tg(Camk2a-ITM2B)8.4Ldad
Transgene Detail

Summary

• Symbol: Tg(Camk2a-ITM2B)8.4Ldad
• Name: transgene insertion 8.4, Luciano D'Adamio
• MGI ID: MGI:3810989
• Synonyms: BRI2-8.4
• Transgene: Tg(Camk2a-ITM2B)8.4Ldad Location: unknown
• Alliance: Tg(Camk2a-ITM2B)8.4Ldad page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-ITM2B)8.4Ldad expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ITM2B (9445)

  Itm2b

  (MGI:1309517)

• Mutation details: An approximately 8.5 kb genomic DNA fragment located upstream of the transcription initiation site of Camk2a including the transcription start site and 84 bp of the 5' noncoding exon is followed by a hybrid intron, a human ITM2B cDNA and an SV40 polyadenylation site. Two lines (8.4 and 5.5) were generated that differed in expression levels with line 8.4 having higher expression levels compared to line 5.5. This is a representative record for these 2 lines. (J:138796)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:138796 Matsuda S, et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008 Aug 27;28(35):8668-76
• All: 2 reference(s)