Ptk2b^tm1Okig
Targeted Allele Detail

Summary

• Symbol: Ptk2b^tm1Okig
• Name: PTK2 protein tyrosine kinase 2 beta; targeted mutation 1, Mitsuhiko Okigaki
• MGI ID: MGI:3811004
• Gene: Ptk2b Location: Chr14:66390706-66518501 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Ptk2b^tm1Okig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139849
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted in an unspecified exon. Absence of protein product was confirmed immunologically. (J:139849)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2b Mutation: 57 strains or lines available

Notes

ES cells of WW strain were used.

References

• Original: J:139849 Matsui A, et al., Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function. Circulation. 2007 Aug 28;116(9):1041-51
• All: 9 reference(s)