Fem1b^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Fem1b^tm1Mms
• Name: fem 1 homolog b; targeted mutation 1, Michael M Shen
• MGI ID: MGI:3811024
• Gene: Fem1b Location: Chr9:62699106-62718930 bp, - strand Genetic Position: Chr9, 33.87 cM
• Alliance: Fem1b^tm1Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by immunohistochemistry on 14 week testes. (J:139640)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fem1b Mutation: 29 strains or lines available

References

• Original: J:139640 Wang X, et al., Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Dev Dyn. 2008 Sep 24;237(10):2963-2972
• All: 1 reference(s)