Syne2^tm1Ngl
Targeted Allele Detail

Summary

• Symbol: Syne2^tm1Ngl
• Name: spectrin repeat containing, nuclear envelope 2; targeted mutation 1, Angelika A Noegel
• MGI ID: MGI:3811076
• Synonyms: Nesprin-2deltaABD
• Gene: Syne2 Location: Chr12:75865092-76157702 bp, + strand Genetic Position: Chr12, 33.11 cM
• Alliance: Syne2^tm1Ngl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a neo cassette eliminating more than half of the actin binding domain. (J:139778)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne2 Mutation: 297 strains or lines available

References

• Original: J:139778 Luke Y, et al., Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci. 2008 Jun 1;121(Pt 11):1887-98
• All: 2 reference(s)