Fez1^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fez1^tm1Kei
• Name: fasciculation and elongation protein zeta 1; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:3811164
• Gene: Fez1 Location: Chr9:36733160-36790220 bp, + strand Genetic Position: Chr9, 20.69 cM
• Alliance: Fez1^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139974
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the translation initiation codon, was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:139974)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fez1 Mutation: 35 strains or lines available

References

• Original: J:139974 Sakae N, et al., Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum Mol Genet. 2008 Oct 15;17(20):3191-203
• All: 1 reference(s)