Mir223^tm1Fcam
Targeted Allele Detail

Summary

• Symbol: Mir223^tm1Fcam
• Name: microRNA 223; targeted mutation 1, Fernando D Camargo
• MGI ID: MGI:3811186
• Synonyms: miR-223^-
• Gene: Mir223 Location: ChrX:95286423-95286532 bp, + strand Genetic Position: ChrX, 42.69 cM
• Alliance: Mir223^tm1Fcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140009
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire 110 bp locus was replaced by a neomycin resistance cassette. Northern blot analysis of granulocyte RNA from hemizygous mice revealed a complete absence of locus expression. (J:140009)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir223 Mutation: 5 strains or lines available

References

• Original: J:140009 Johnnidis JB, et al., Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature. 2008 Feb 28;451(7182):1125-9
• All: 38 reference(s)