Tg(Sftpc-Mirn17-92)1Blh
Transgene Detail

Summary

• Symbol: Tg(Sftpc-Mirn17-92)1Blh
• Name: transgene insertion 1, Brigid L Hogan
• MGI ID: MGI:3811265
• Synonyms: Sftpc-miR-17-92
• Transgene: Tg(Sftpc-Mirn17-92)1Blh Location: unknown
• Alliance: Tg(Sftpc-Mirn17-92)1Blh page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Sftpc-Mirn17-92)1Blh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mirc1 (MGI:3790484)

• Mutation details: The promoter was used to drive expression in lung epithelium. Eight expressing founders were generated and only one line was maintained (no line name given). (J:128019)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Sftpc-Mirn17-92)1Blh/0	involves: FVB * ICR

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
growth/size/body	√
pulmonary hyperplasia	√
mortality/aging	√
perinatal lethality, incomplete penetrance	√
respiratory system	√
abnormal lung morphology	√
pulmonary hyperplasia	√
abnormal lung development	√
abnormal pulmonary alveolus morphology	√
atelectasis	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128019 Lu Y, et al., Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007 Oct 15;310(2):442-53
• All: 1 reference(s)