Tg(THY1-SNCA*A53T)F53Sud
Transgene Detail

Summary

• Symbol: Tg(THY1-SNCA*A53T)F53Sud
• Name: transgene insertion F53, Thomas C Sudhof
• MGI ID: MGI:3811331
• Synonyms: F53
• Transgene: Tg(THY1-SNCA*A53T)F53Sud Location: unknown
• Alliance: Tg(THY1-SNCA*A53T)F53Sud page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(THY1-SNCA*A53T)F53Sud expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgenic construct carries the A53T mutant form of the human SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. Expression of the transgene is 10-fold increased in the brain and 20-fold in the spinal cord. (J:140019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:140019 Sudhof TC, Generation of a mutant A53T human alpha-synuclein transgene. MGI Direct Data Submission. 2008
• All: 1 reference(s)