Tlr7^rsq2
Chemically induced Allele Detail

Summary

• Symbol: Tlr7^rsq2
• Name: toll-like receptor 7; resiquimod unresponsive 2
• MGI ID: MGI:3811335
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^rsq2 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered in a toll-like receptor (TLR) signaling screen of the G3 progeny of an ENU mutagenized male mouse. It has been identified as an A to T transversion at nucleotide position 732 (Genbank: NM_133211), in the third and final exon, that results in the replacement of a highly conserved asparagine by tyrosine at amino acid position 182 of the protein (N182Y), in the fifth leucine rich repeat (LRR) of the receptor's ectodomain.
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 20 strains or lines available

References

• Original: J:140020 Siggs OM, et al., Record for "rsq2" updated October 20th, 2008. MGI Direct Data Submission. 2008
• All: 1 reference(s)