Tg(Cryaa-cre,Tyr)39Mlr
Transgene Detail

Summary

• Symbol: Tg(Cryaa-cre,Tyr)39Mlr
• Name: transgene insertion 39, Mike Robinson
• MGI ID: MGI:3811526
• Synonyms: CPV2/Cre, MLR39-Cre
• Transgene: Tg(Cryaa-cre,Tyr)39Mlr Location: unknown
• Alliance: Tg(Cryaa-cre,Tyr)39Mlr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cryaa-cre,Tyr)39Mlr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cryaa (MGI:88515)

• Mutation details: A cre recombinase gene was driven by an alpha A crystallin promoter consisting of -282/+43 of the mouse Cryaa gene. Seven founder lines were generated using this construct, which in this line was coinjected with a tyrosinase minigene. Line 39 has expression of the transgene in lens fiber cells but not in the surrounding lens epithelium. Ectopic expression of the transgene was also detected in the retinal pigment epithelium and in the ciliary bodies of the eye. (J:90292)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cryaa (mouse) Summary of all recombinase alleles driven by Cryaa. Comparative matrix view of recombinase activities Alliance mouse Cryaa gene page

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90292 Zhao H, et al., Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1930-9
• All: 9 reference(s)