Adm^tm1Mtnz
Targeted Allele Detail

Summary

• Symbol: Adm^tm1Mtnz
• Name: adrenomedullin; targeted mutation 1, Alfredo Martinez
• MGI ID: MGI:3811632
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1Mtnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138817
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A lxoP site was inserted upstream of the first exon. An FRT-flanked neo cassette with a 5' loxP was inserted downstream of the last exon. Flp-mediated recombination removed the neo cassette and left the 4 exons floxed. (J:138817)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:138817 Fernandez AP, et al., Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12581-6
• All: 10 reference(s)