Adm^tm1.1Mtnz
Targeted Allele Detail

Summary

• Symbol: Adm^tm1.1Mtnz
• Name: adrenomedullin; targeted mutation 1.1, Alfredo Martinez
• MGI ID: MGI:3811634
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1.1Mtnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138817
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP sites were introduced into both 5' and 3' of 4 exons of the gene from Adm^tm1Mtnz was deleted by crossing with animals expressing cre under a ubiquitous promoter (unspecified) resulting in a null allele. Homozygous mice showed comlete lack of protein product from conception. (J:138817)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:138817 Fernandez AP, et al., Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12581-6
• All: 1 reference(s)