Fgf16^tm1Nit
Targeted Allele Detail

Summary

• Symbol: Fgf16^tm1Nit
• Name: fibroblast growth factor 16; targeted mutation 1, Nobuyuki Itoh
• MGI ID: MGI:3811646
• Gene: Fgf16 Location: ChrX:104807885-104818545 bp, + strand Genetic Position: ChrX, 47.2 cM, cytoband C3
• Alliance: Fgf16^tm1Nit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139637
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Most of exons 2 and all of exon 3 were replaced with an IRES-LacZ- polyA/PGK-neo cassette. Gene inactivation was confirmed by RT-PCR analysis on heart RNA isolated from hemizygotes. (J:139637)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ot1	Fgf16^tm1Nit/Y	C57BL/6-Fgf16^tm1Nit

Phenotypes:

Affected Systems	ot1
show or hide all annotated terms Sex:
cardiovascular system	√
decreased heart weight	√
heart hypoplasia	√
abnormal heart left ventricle morphology	√
abnormal fetal cardiomyocyte proliferation	√
cellular	√
abnormal fetal cardiomyocyte proliferation	√
muscle	√
abnormal fetal cardiomyocyte proliferation	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf16 Mutation: 7 strains or lines available

References

• Original: J:139637 Hotta Y, et al., Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart. Dev Dyn. 2008 Sep 24;237(10):2947-2954
• All: 2 reference(s)