Sod3^tm1Dgh
Targeted Allele Detail

Summary

• Symbol: Sod3^tm1Dgh
• Name: superoxide dismutase 3, extracellular; targeted mutation 1, David G Harrison
• MGI ID: MGI:3811715
• Synonyms: ecSOD^loxp
• Gene: Sod3 Location: Chr5:52521146-52527080 bp, + strand Genetic Position: Chr5, 27.92 cM
• Alliance: Sod3^tm1Dgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139655
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed by the following targeting strategy. A single loxP site was inserted into intron 1 at the AatII site and a loxP-flanked neomycin resistance cassette was inserted at ApaI site 3' of exon 2. The neomycin cassette was removed by transient expression of cre-recombinase, leaving exon 2 floxed. (J:139655)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod3 Mutation: 13 strains or lines available

References

• Original: J:139655 Gongora MC, et al., Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. Am J Pathol. 2008 Oct;173(4):915-26
• All: 7 reference(s)