Irf1^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irf1^M1Btlr
• Name: interferon regulatory factor 1; mutation 1, Bruce Beutler
• MGI ID: MGI:3811824
• Synonyms: Endeka
• Gene: Irf1 Location: Chr11:53660841-53669200 bp, + strand Genetic Position: Chr11, 32.0 cM
• Alliance: Irf1^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in an ENU mutagenesis screen, comprises an A to G transition at nucleotide position 345 (Genbank Accession NM_008390), in the third of the gene's 10 exons, resulting in replacement of aspartic acid by glycine at amino acid position 47 (D47G). (J:162995)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf1 Mutation: 21 strains or lines available

Notes

The NK cell phenotype is inherited in an autosomal dominant manner, whereas the CD8⁺ T cell phenotype behaves as an autosomal recessive trait.

References

• Original: J:162995 Krebs P, et al., Record for endeka, updated 3 Feb 2010, accessed 27 Aug 2010. MGI Direct Data Submission. 2010
• All: 1 reference(s)