Slc2a1^Rgsc200
Chemically induced Allele Detail

Summary

• Symbol: Slc2a1^Rgsc200
• Name: solute carrier family 2 (facilitated glucose transporter), member 1; RIKEN Genomic Sciences Center (GSC), 200
• MGI ID: MGI:3811855
• Synonyms: Glut1^Rgsc200, M100200
• Gene: Slc2a1 Location: Chr4:118966001-118994527 bp, + strand
• Alliance: Slc2a1^Rgsc200 page

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in an ENU mutagenesis screen. Sequence analysis of the gene revealed a T-to-C mutation in exon 7. The mutation resulted in a substitution of serine with proline at residue 324 of the encoded protein. RT-qPCR analysis showed a significant increase of Slc2a1 mRNA expression in the forebrain of adult heterozygotes. Immunoblotting showed no significant alterations of SLC2A1 protein expression in the forebrain of adult heterozygotes relative to wild-type controls. (J:281292)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a1 Mutation: 60 strains or lines available

References

• Original: J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008
• All: 2 reference(s)