Insr^Rgsc294
Chemically induced Allele Detail

Summary

• Symbol: Insr^Rgsc294
• Name: insulin receptor; RIKEN Genomic Sciences Center (GSC), 294
• MGI ID: MGI:3811869
• Synonyms: Insr^N1154S, M100294
• Gene: Insr Location: Chr8:3200922-3329649 bp, - strand Genetic Position: Chr8, 1.82 cM
• Alliance: Insr^Rgsc294 page

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutatation, identified in an ENU mutagenesis screen, comprises an A to G transition in exon 18 that results in the substitution of serine for asparagine at amino acid position 1154 (N1154S), in the tyrosine kinase domain of the receptor. (J:133634)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Insr Mutation: 95 strains or lines available

References

• Original: J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008
• All: 2 reference(s)