Ldlr^Rgsc366
Chemically induced Allele Detail

Summary

• Symbol: Ldlr^Rgsc366
• Name: low density lipoprotein receptor; RIKEN Genomic Sciences Center (GSC), 366
• MGI ID: MGI:3811877
• Synonyms: M100366
• Gene: Ldlr Location: Chr9:21634872-21661215 bp, + strand Genetic Position: Chr9, 7.87 cM
• Alliance: Ldlr^Rgsc366 page

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered in an ENU mutagenesis screen, has been identified as a point mutation in the low density lipoprotein receptor gene (C146R).
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ldlr Mutation: 81 strains or lines available

Notes

The founder mouse also had a kinked tail (Rgsc366a), which was found to segregate independently of the cholesterol phenotype. (J:133634)

References

• Original: J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008
• All: 3 reference(s)