Tmprss6^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tmprss6^m2Btlr
• Name: transmembrane serine protease 6; mutation 2, Bruce Beutler
• MGI ID: MGI:3812005
• Synonyms: zorro, zro
• Gene: Tmprss6 Location: Chr15:78323867-78352834 bp, - strand Genetic Position: Chr15, 37.49 cM, cytoband E2
• Alliance: Tmprss6^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered by its visible phenotype among the G3 progeny of an ENU mutagenized male mouse. The mutation has been identified as a C to T transition in the 15th of the gene's 18 exons, at nucleotide position 2004 (Genbank Accession NM_027902), that converts the codon (CGA) for arginine 599 into a premature termination codon (TGA) (R599Ter), truncating the protein by 212 amino acids at its C terminus and interrupting the protease domain. (J:140084)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmprss6 Mutation: 46 strains or lines available

References

• Original: J:140084 Du X, et al., Zorro is a mutation of Tmprss6. MGI Direct Data Submission. 2008
• All: 1 reference(s)