Eya1^tm1Px
Targeted Allele Detail

Summary

• Symbol: Eya1^tm1Px
• Name: EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Pin-Xian Xu
• MGI ID: MGI:3812010
• Synonyms: Eya1^lacZ
• Gene: Eya1 Location: Chr1:14239178-14380459 bp, - strand Genetic Position: Chr1, 4.31 cM
• Alliance: Eya1^tm1Px page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140027
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous start codon as well as the exon 1 was replaced with a promoterless Escherichia coli ATG-lacZ-poly(A) cassette and a PGK-neo gene. Genomic PCR was used to confirm correct targeting of the construct. (J:140027)

Expression

In Mice Carrying this Mutation:

46 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eya1 Mutation: 56 strains or lines available

References

• Original: J:140027 Zou D, et al., Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56
• All: 5 reference(s)