Zbtb20^tm1Wpjz
Targeted Allele Detail

Summary

• Symbol: Zbtb20^tm1Wpjz
• Name: zinc finger and BTB domain containing 20; targeted mutation 1, Weiping J Zhang
• MGI ID: MGI:3812013
• Synonyms: ZBTB20^flox
• Gene: Zbtb20 Location: Chr16:42728008-43462981 bp, + strand Genetic Position: Chr16, 28.44 cM, cytoband B4
• Alliance: Zbtb20^tm1Wpjz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140053
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was placed upstream of exon 6 and an additional loxP site was placed downstream of exon 6. PC3 ES cells contain a protamine-cre transgene, Tg(Prm-cre)70Og, which expresses Cre recombinase under control of the male-germline specific protamine promoter. Cre-mediated excision removed the neo cassette upon transmission from male chimeras, leaving exon 6 flanked by loxP sites. (J:140053)

Expression

In Mice Carrying this Mutation:

91 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb20 Mutation: 58 strains or lines available

References

• Original: J:140053 Xie Z, et al., Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10859-64
• All: 13 reference(s)