Chek2^tm1Pjs
Targeted Allele Detail

Summary

• Symbol: Chek2^tm1Pjs
• Name: checkpoint kinase 2; targeted mutation 1, Peter J Stambrook
• MGI ID: MGI:3812090
• Synonyms: Chk2*1100delC
• Gene: Chek2 Location: Chr5:110987845-111022011 bp, + strand Genetic Position: Chr5, 53.73 cM, cytoband F
• Alliance: Chek2^tm1Pjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118262
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted into intron 12 and exon 13 was replaced with one containing deletion of cytosine at position 1100 (1100delC). This single nucleotide deletion results in a frame shift and premature termination within the kinase domain. (J:118262)

Tumor Data

List all tumor models in MMHCdb carrying Chek2^tm1Pjs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chek2 Mutation: 54 strains or lines available

References

• Original: J:118262 Bahassi el M, et al., The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model. Mutat Res. 2007 Mar 1;616(1-2):201-9
• All: 4 reference(s)